Purify desire by making Krishna the center, not the self; prema flowers only through regulated devotional practice and freedom from material designations.Listen — Srila Prabhupada Uvaca
Pradyumna: ...bhagavate vāsudevāya. Oṁ namo bhagavate vāsudevāya. [devotees repeat] [leads chanting of verse, etc.] kāmo manyur mado lobhaḥ śoka-moha-bhayādayaḥ karma-bandhaś ca yan-mūlaḥ svīkuryāt ko nu tad budhaḥ [SB 5.6.5] [break] [02:46] Translation: "The mind is the root cause of lust, anger, pride, greed, lamentation, illusion and fear. Combined, these constitute bondage to fruitive activity.
What learned man would put faith in the mind?" [break]
Prabhupāda: kāmo manyur mado lobhaḥ śoka-moha-bhayādayaḥ karma-bandhaś ca yan-mūlaḥ svīkuryāt ko nu tad budhaḥ [SB 5.6.5] So budha means one who is aware of everything, jñānī. Budhā bhāva-samanvitaḥ [Bg 10.8]. Such budha, intelligent person, will not accept these base qualities. Kāma, manyur, means greediness, lusty; madaḥ—madness; lobha...
Mada, mada? Kāmo manyur mada. What is mada? Madness?
Mada—pride, yes. Kāmo manyur mado lobhaḥ—greediness; śoka—lamentation; moha—illusion; Bhayāt dvitīyābhiniveśataḥ syāt. [SB 11.2.37] When we are too much materially absorbed, then there is bhaya. Āhāra-nidrā-bhaya-maithunaṁ ca sāmānyam etat paśubhir narāṇām [Hitopadeśa 25(1)]. So long we are interested in bodily concept of life, these things are manifested. And when we are spiritually identified, so there is no more kāma-lobha-bhaya-śoka-bhayādayaḥ. Śoka-moha-bhaya apahaḥ.
[SB 11.21.18] Spiritually means, advanced means, śoka moha bhaya, these things are not existing. These are the symptoms of karma-bandha. But if we devote ourself in the bhakti-yoga, in the service of the Lord, then the face of these things will change. The face of these things will change.
Kāma, kṛṣṇa-kāma-karmārpaṇe. [Prema-bhakti-candrikā. Song 3, stanza 10] Narottama dāsa Ṭhākura has advised that kāma and the desire will be transformed how to serve Kṛṣṇa. Kṛṣṇārthe akhila-ceṣṭa, the same thing.